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interests / talk.origins / Apoptosis (cell death)

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o Apoptosis (cell death)erik simpson

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Apoptosis (cell death)

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From: eastside...@gmail.com (erik simpson)
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Subject: Apoptosis (cell death)
Date: Thu, 7 Mar 2024 11:03:11 -0800
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 by: erik simpson - Thu, 7 Mar 2024 19:03 UTC

Apoptotic Factors Are Evolutionarily Conserved Since Mitochondrial
Domestication

"The mechanisms initiating apoptotic programmed cell death in diverse
eukaryotes are very similar. Basically, the mitochondrial permeability
transition activates apoptotic proteases, DNases, and flavoproteins such
as apoptosis-inducing factors (AIFs). According to the hypothesis of the
endosymbiotic origin of apoptosis, these mechanisms evolved during
mitochondrial domestication. Various phylogenetic analyses, including
ours, have suggested that apoptotic factors were eubacterial
protomitochondrial toxins used for killing protoeukaryotic hosts. Here,
we tested whether the function of yeast Saccharomyces cerevisiae
apoptotic proteases (metacaspases Mca1 and Nma111), DNase Nuc1, and
flavoprotein Ndi1 can be substituted with orthologs from remotely
related eukaryotes such as plants, protists, and eubacteria. We found
that orthologs of remotely related eukaryotic and even eubacterial
proteins can initiate apoptosis in yeast when triggered by chemical
stresses. This observation suggests that apoptotic mechanisms have been
maintained since mitochondrial domestication, which occurred
approximately 1,800 Mya. Additionally, it supports the hypothesis that
some of these apoptotic factors could be modified eubacterial toxins."

https://academic.oup.com/gbe/article/15/10/evad154/7250219


interests / talk.origins / Apoptosis (cell death)

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